Beetle was first seen raiding a S.H.I.E.L.D. cargo vessel to unleash the Green Goblin. He was soon seen again in New York. Being tracked down by Spider Man, he led the hero on a chase around the city. Breaking into a lab, he stole a sample of the Sandman before escaping into the Latverian embassy.

Reappearing, he got into a battle with Venom in order to gather a sample of him as well, despite his efforts though, Venom defeats him, leaving him for dead. In the DS version, after he wakes up, he sees his armor being covered in the samples of the symbiotes, meaning that he achieved his mission by gathering the samples required.