Vulture was one of the old enemies of Spider-Man. When the Regent took over Regency, Toomes became a member of his Sinister Six.

When Kraven the Hunter figured out that Spider-Man was a father, the Six hatched a plan to capture Spidey and his family at Public School 122 Mamie Fay. While their plan worked, his wife and daughter were rescued by S.H.I.E.L.D..

Noticing his family's disappearance, Spider-Man beat his enemies in a blind rage, incapacitating the Vulture.