Agent Deadpool was a symbiote who was bonded to Deadpool in the Sym-Soldier Program to fight Codex Hive. However, the war against Codex turned out to be a losing battle that saw many of the world's heroes and villains killed or turned into Codex's symbiote army. As Codex conquered Earth and began converting the population into symbiote-aggregates of his hive mind, Peter and the remaining symbiote-soldiers retreated to the former S.H.I.E.L.D. tunnels beneath the city of Manhattan. While investigating an incident involving the Avengers, the resistance encountered Venom from Earth-616 and his son Dylan Brock, though they were intercepted by the Codex symbiotes which caused Deadpool to use the bombs to blast the symbiote with him. Deadpool and his symbiote then regenerated just in time to warn Annie and Eddie when the newly bonded Scorpion ambushed them in the sewers. He later helped with the main assault on the Hive itself where Dylan managed to sever his counterpart's connection to Knull causing the horde of symbiotes he had created to perish and the world slowly returned to normal, though the Sym-Soldier Program symbiotes were unaffected.