Agent Spider-Man was a symbiote who was bonded to Peter Parker in the Sym-Soldier Program to fight Codex Hive. However, the war against Codex turned out to be a losing battle that saw many of the world's heroes and villains killed or turned into Codex's symbiote army. As Codex conquered Earth and began converting the population into symbiote-aggregates of his hive mind, Peter and the remaining symbiote-soldiers retreated to the former S.H.I.E.L.D. tunnels beneath the city of Manhattan. While investigating an incident involving the Avengers, the resistance encountered Earth-616's Venom and his son Dylan Brock who assisted the resistance in taking down Codex by using Dylan from their world to sever his connection to Knull, after severing his connection to the Dark God, the horde of symbiotes he had created perished and the world slowly returned to normal although the Sym-Soldier Program symbiotes were unaffected.